This program project grant within the Department of Radiation Therapy, Harvard Medical School, supports a variety of research projects addressed to the interaction between the major therapeutic modalities used in the treatment of cancer. These are radation, chemotherapeutic agents, and immunological factors. The research projects span the study of these interactions at the molecular through tissue levels. Therefore, the major purpose of this program project is to provide the focus for multi-disciplinary research directed to the improved management of human cancer and to establish opportunities for research collaboration between individuals whose major interest is oncologic medicine.